Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant

Leukocyte Adhesion Deficiency Associated with Neonatal Septic Hip in a Late Preterm Infant

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Leukocyte adhesion deficiency is a rare primary immunodeficiency and autosomal recessive disorder caused by a mutation in the Breast Plate gene encoding CD18, which is a constituent of leukocyte integrins.Clinical features usually begin with a delay in the separation of the umbilical cord in the neonatal period, and are characterized by marked leukocytosis with infection, delayed wound healing, and repeated bacterial and fungal infections.We experienced a case of leukocyte adhesion deficiency diagnosed in the neonatal period, in which a late preterm infant admitted to neonatal intensive Washing Machine Control Module care unit presented with a septic hip.

Flow cytometry analysis of whole blood showed a decrease in the expression of CD11b/CD18.This is the first case of leukocyte adhesion deficiency with neonatal septic hip diagnosed in Korea.